PL3.6 Targeting GSK-3 activity promotes mitotic catastrophe via centrosome destabilisation and enhances the effect of radiotherapy in glioma models

BACKGROUND: Targeting kinases as regulators of cellular processes that drive cancer progression is a promising approach to improve patient outcome in GBM management. The glycogen synthase kinase 3 (GSK-3) plays a role in cancer progression and is known for its pro-proliferative activity in gliomas....

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Podrobná bibliografie
Vydáno v:Neuro Oncol
Hlavní autoři: Bruning-Richardson, A, Sanganee, H, Barry, S, Tams, D, Brend, T, King, H, Morton, R, Ward, T, Steele, L, Shaw, G, Esteves, F, Droop, A, Lawler, S, Short, S
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2019
Témata:
Oral Presentations
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6795005/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz126.009
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