Postnatal Expression of Hu-Bcl-2 Gene inLurcher Mutant Mice Fails to Rescue Purkinje Cells but Protects Inferior Olivary Neurons from Target-Related Cell Death

The Lurcher mutant has been extensively studied as a model for cell-autonomous and target-related cell death, yet there are still many unknowns concerning the mechanisms of neuronal degeneration in this mutant. As a key regulator of apoptosis, a bcl-2transgene has been overexpressed in the heterozyg...

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Vydáno v:J Neurosci
Hlavní autoři: Zanjani, H. S., Vogel, M. W., Martinou, J. C., Delhaye-Bouchaud, N., Mariani, J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Neuroscience 1998
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6793412/
https://ncbi.nlm.nih.gov/pubmed/9412510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.18-01-00319.1998
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