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Bax Inactivation in Lurcher Mutants Rescues Cerebellar Granule Cells But Not Purkinje Cells or Inferior Olivary Neurons
Lurcher is a gain-of-function mutation in the δ2 glutamate receptor gene (Grid2) that turns the receptor into a leaky ion channel. The expression of the Lurcher gene in heterozygous (Grid2(Lc/+)) mutants induces the death of almost all Purkinje cells starting from the second postnatal week. Ninety p...
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| Pubblicato in: | J Neurosci |
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| Autori principali: | , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Society for Neuroscience
2000
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6772316/ https://ncbi.nlm.nih.gov/pubmed/10884318 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.20-14-05339.2000 |
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