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Dopamine Inactivates Tryptophan Hydroxylase and Forms a Redox-Cycling Quinoprotein: Possible Endogenous Toxin to Serotonin Neurons
Exposure of tryptophan hydroxylase (TPH), the initial and rate-limiting enzyme in the biosynthesis of the neurotransmitter serotonin, to dopamine under mild oxidizing conditions (iron + H(2)O(2)) or in the presence of tyrosinase results in a concentration-dependent inactivation of the enzyme. Dopami...
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| Published in: | J Neurosci |
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| Main Authors: | , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Society for Neuroscience
1998
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6793230/ https://ncbi.nlm.nih.gov/pubmed/9736634 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.18-18-07111.1998 |
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