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Molecular Mechanism of the Inactivation of Tryptophan Hydroxylase by Nitric Oxide: Attack on Critical Sulfhydryls that Spare the Enzyme Iron Center
Tryptophan hydroxylase (TPH), the initial and rate-limiting enzyme in the biosynthesis of the neurotransmitter serotonin (5-HT), is irreversibly inactivated by nitric oxide (NO). We have expressed brain TPH as a recombinant glutathione-S-transferase fusion protein and delineated the catalytic domain...
Wedi'i Gadw mewn:
| Cyhoeddwyd yn: | J Neurosci |
|---|---|
| Prif Awduron: | , |
| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
Society for Neuroscience
1997
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| Pynciau: | |
| Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6573465/ https://ncbi.nlm.nih.gov/pubmed/9295371 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.17-19-07245.1997 |
| Tagiau: |
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