Staurosporine-Induced Apoptosis of Cultured Rat Hippocampal Neurons Involves Caspase-1-Like Proteases as Upstream Initiators and Increased Production of Superoxide as a Main Downstream Effector

We induced apoptosis in cultured rat hippocampal neurons by exposure to the protein kinase inhibitor staurosporine (30 nm, 24 hr). Treatment with the antioxidant (±)-α-tocopherol (100 μm) or the superoxide dismutase-mimetic manganese tetrakis (4-benzoyl acid) porphyrin (1 μm) significantly reduced s...

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Bibliographic Details
Published in:J Neurosci
Main Authors: Krohn, Aaron J., Preis, Elke, Prehn, Jochen H. M.
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 1998
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6792864/
https://ncbi.nlm.nih.gov/pubmed/9763465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.18-20-08186.1998
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