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Staurosporine-Induced Apoptosis of Cultured Rat Hippocampal Neurons Involves Caspase-1-Like Proteases as Upstream Initiators and Increased Production of Superoxide as a Main Downstream Effector

We induced apoptosis in cultured rat hippocampal neurons by exposure to the protein kinase inhibitor staurosporine (30 nm, 24 hr). Treatment with the antioxidant (±)-α-tocopherol (100 μm) or the superoxide dismutase-mimetic manganese tetrakis (4-benzoyl acid) porphyrin (1 μm) significantly reduced s...

詳細記述

保存先:
書誌詳細
出版年:J Neurosci
主要な著者: Krohn, Aaron J., Preis, Elke, Prehn, Jochen H. M.
フォーマット: Artigo
言語:Inglês
出版事項: Society for Neuroscience 1998
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6792864/
https://ncbi.nlm.nih.gov/pubmed/9763465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.18-20-08186.1998
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