1-Methyl-4-phenyl-1,2,3,6-tetrahydropyride Neurotoxicity Is Attenuated in Mice Overexpressing Bcl-2

The proto-oncogene Bcl-2 rescues cells from a wide variety of insults. Recent evidence suggests that Bcl-2 protects against free radicals and that it increases mitochondrial calcium-buffering capacity. The neurotoxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyride (MPTP) is thought to involve both...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Yang, Lichuan, Matthews, Russell T., Schulz, Jörg B., Klockgether, Thomas, Liao, Andrew W., Martinou, Jean-Claude, Penney, John B., Hyman, Bradley T., Beal, M. Flint
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 1998
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6792836/
https://ncbi.nlm.nih.gov/pubmed/9763461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.18-20-08145.1998
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