Customized MethylC-Capture Sequencing to Evaluate Variation in the Human Sperm DNA Methylome Representative of Altered Folate Metabolism

BACKGROUND: The sperm DNA methylation landscape is unique and critical for offspring health. If gamete-derived DNA methylation escapes reprograming in early embryos, epigenetic defects in sperm may be transmitted to the next generation. Current techniques to assess sperm DNA methylation show bias to...

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Udgivet i:Environ Health Perspect
Main Authors: Chan, Donovan, Shao, Xiaojian, Dumargne, Marie-Charlotte, Aarabi, Mahmoud, Simon, Marie-Michelle, Kwan, Tony, Bailey, Janice L., Robaire, Bernard, Kimmins, Sarah, San Gabriel, Maria C., Zini, Armand, Librach, Clifford, Moskovtsev, Sergey, Grundberg, Elin, Bourque, Guillaume, Pastinen, Tomi, Trasler, Jacquetta M.
Format: Artigo
Sprog:Inglês
Udgivet: Environmental Health Perspectives 2019
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Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6792365/
https://ncbi.nlm.nih.gov/pubmed/31393794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1289/EHP4812
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