Peptide-Cleavable Self-immolative Maytansinoid Antibody–Drug Conjugates Designed To Provide Improved Bystander Killing

[Image: see text] A new type of antibody–drug conjugate (ADC) has been prepared that contains a sulfur-bearing maytansinoid attached to an antibody via a highly stable tripeptide linker. Once internalized by cells, proteases in catabolic vesicles cleave the peptide of the ADC’s linker causing self-i...

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Udgivet i:ACS Med Chem Lett
Main Authors: Costoplus, Juliet A., Veale, Karen H., Qiu, Qifeng, Ponte, Jose F., Lanieri, Leanne, Setiady, Yulius, Dong, Ling, Skaletskaya, Anna, Bartle, Laura M., Salomon, Paulin, Wu, Rui, Maloney, Erin K., Kovtun, Yelena V., Ab, Olga, Lai, Kate, Chari, Ravi V. J., Widdison, Wayne C.
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2019
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6792174/
https://ncbi.nlm.nih.gov/pubmed/31620224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.9b00310
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