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A head-to-toe dimerization has physiological relevance for ligand-induced inactivation of protein tyrosine receptor type Z
Protein-tyrosine phosphatase (PTPase) receptor type Z (PTPRZ) has two receptor isoforms, PTPRZ-A and -B, containing tandem intracellular PTP-D1 and -D2 domains, with only D1 being active. Pleiotrophin (PTN) binding to the extracellular PTPRZ region leads to inactivation of its PTPase activity, there...
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| Pubblicato in: | J Biol Chem |
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| Autori principali: | , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Biochemistry and Molecular Biology
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6791311/ https://ncbi.nlm.nih.gov/pubmed/31416834 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.007878 |
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