Loss of FBXO7 results in a Parkinson's‐like dopaminergic degeneration via an RPL23–MDM2–TP53 pathway

The field of Parkinson's disease research has been impeded by the absence of animal models that clearly phenocopy the features of this neurodegenerative condition. Mutations in FBXO7/PARK15 are associated with both sporadic Parkinson's disease and a severe form of autosomal recessive early...

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Detalhes bibliográficos
Publicado no:J Pathol
Main Authors: Stott, Simon RW, Randle, Suzanne J, Al Rawi, Sara, Rowicka, Paulina A, Harris, Rebecca, Mason, Bethany, Xia, Jing, Dalley, Jeffrey W, Barker, Roger A, Laman, Heike
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley & Sons, Ltd 2019
Assuntos:
Original Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6790581/
https://ncbi.nlm.nih.gov/pubmed/31144295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/path.5312
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