Glioblastoma ablates pericytes antitumor immune function through aberrant up-regulation of chaperone-mediated autophagy

The contractile perivascular cells, pericytes (PC), are hijacked by glioblastoma (GB) to facilitate tumor progression. PC’s protumorigenic function requires direct interaction with tumor cells and contributes to the establishment of immunotolerance to tumor growth. Cancer cells up-regulate their own...

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Bibliographische Detailangaben
Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Valdor, Rut, García-Bernal, David, Riquelme, Dolores, Martinez, Carlos M., Moraleda, Jose M., Cuervo, Ana Maria, Macian, Fernando, Martinez, Salvador
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2019
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PNAS Plus
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6789971/
https://ncbi.nlm.nih.gov/pubmed/31548426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1903542116
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