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Chaperone mediated autophagy regulates T cell responses through targeted degradation of negative regulators of T cell activation
Chaperone mediated autophagy (CMA) targets soluble proteins for lysosomal degradation. Here we show that CMA is activated in T cells in response to T cell receptor (TCR) engagement, which induces the expression of the lysosomal CMA receptor, LAMP-2A. In activated T cells, CMA targets the ubiquitin l...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4208273/ https://ncbi.nlm.nih.gov/pubmed/25263126 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3003 |
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