Inhibition of spindle extension through the yeast S phase checkpoint is coupled to replication fork stability and the integrity of centromeric DNA

Budding yeast treated with hydroxyurea (HU) activate the S phase checkpoint kinase Rad53, which prevents DNA replication forks from undergoing aberrant structural transitions and nuclease processing. Rad53 is also required to prevent premature extension of the mitotic spindle that assembles during a...

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Veröffentlicht in:Mol Biol Cell
Hauptverfasser: Julius, Jeff, Peng, Jie, McCulley, Andrew, Caridi, Chris, Arnak, Remigiusz, See, Colby, Nugent, Constance I., Feng, Wenyi, Bachant, Jeff
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Cell Biology 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6789157/
https://ncbi.nlm.nih.gov/pubmed/31509480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E19-03-0156
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