Centromere Replication Timing Determines Different Forms of Genomic Instability in Saccharomyces cerevisiae Checkpoint Mutants During Replication Stress

Yeast replication checkpoint mutants lose viability following transient exposure to hydroxyurea, a replication-impeding drug. In an effort to understand the basis for this lethality, we discovered that different events are responsible for inviability in checkpoint-deficient cells harboring mutations...

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Bibliographic Details
Main Authors: Feng, Wenyi, Bachant, Jeff, Collingwood, David, Raghuraman, M. K., Brewer, Bonita J.
Format: Artigo
Language:Inglês
Published: Genetics Society of America 2009
Subjects:
Investigations
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2787418/
https://ncbi.nlm.nih.gov/pubmed/19805819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.109.107508
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