Depletion of CD40 on CD11c(+) cells worsens the metabolic syndrome and ameliorates hepatic inflammation during NASH

The co-stimulatory CD40-CD40L dyad plays a central role in fine-tuning immune reactions, including obesity-induced inflammation. Genetic ablation of CD40L reduced adipose tissue inflammation, while absence of CD40 resulted in aggravated metabolic dysfunction in mice. During obesity, CD40 expressing...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Aarts, Suzanne, Reiche, Myrthe, den Toom, Myrthe, Gijbels, Marion, Beckers, Linda, Gerdes, Norbert, Lutgens, Esther
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6789104/
https://ncbi.nlm.nih.gov/pubmed/31604965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-50976-6
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