Sufu- and Spop-mediated downregulation of Hedgehog signaling promotes beta cell differentiation through organ-specific niche signals

Human embryonic stem cell-derived beta cells offer a promising cell-based therapy for diabetes. However, efficient stem cell to beta cell differentiation has proven difficult, possibly due to the lack of cross-talk with the appropriate mesenchymal niche. To define organ-specific niche signals, we is...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Yung, Theodora, Poon, Frankie, Liang, Minggao, Coquenlorge, Sabrina, McGaugh, Emily C., Hui, Chi-chung, Wilson, Michael D., Nostro, M. Cristina, Kim, Tae-Hee
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6789033/
https://ncbi.nlm.nih.gov/pubmed/31604927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-12624-5
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