NQO1-dependent, tumor-selective radiosensitization of non-small cell lung cancers

PURPOSE: Development of tumor-specific therapies for the treatment of recalcitrant non-small cell lung cancers (NSCLCs) are urgently needed. Here, we investigated the ability of ß-lapachone (ß-lap, ARQ761 in clinical form) to selectively potentiate the effects of ionizing radiation (IR, 1–3 Gy) in N...

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Pubblicato in:Clin Cancer Res
Autori principali: Motea, Edward A., Huang, Xiumei, Singh, Naveen, Kilgore, Jessica, Williams, Noelle, Xie, Xian-Jin, Gerber, David E., Beg, Muhammad Shaalan, Bey, Erik A., Boothman, David A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6788754/
https://ncbi.nlm.nih.gov/pubmed/30617135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-2560
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