Setmelanotide, a Novel, Selective Melanocortin Receptor-4 Agonist Exerts Anti-inflammatory Actions in Astrocytes and Promotes an Anti-inflammatory Macrophage Phenotype

To date, available treatment strategies for multiple sclerosis (MS) are ineffective in preventing or reversing progressive neurologic deterioration, creating a high, and unmet medical need. One potential way to fight MS may be by limiting the detrimental effects of reactive astrocytes, a key patholo...

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Detalles Bibliográficos
Publicado en:Front Immunol
Autores principales: Kamermans, Alwin, Verhoeven, Tom, van het Hof, Bert, Koning, Jasper J., Borghuis, Lauri, Witte, Maarten, van Horssen, Jack, de Vries, Helga E., Rijnsburger, Merel
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2019
Materias:
Immunology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6788433/
https://ncbi.nlm.nih.gov/pubmed/31636637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.02312
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