Adenosine mediates functional and metabolic suppression of peripheral and tumor-infiltrating CD8(+) T cells

BACKGROUND: Several mechanisms are present in the tumor microenvironment (TME) to impair cytotoxic T cell responses potentially able to control tumor growth. Among these, the accumulation of adenosine (Ado) contributes to tumor progression and represents a promising immunotherapeutic target. Ado has...

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Publicat a:J Immunother Cancer
Autors principals: Mastelic-Gavillet, Beatris, Navarro Rodrigo, Blanca, Décombaz, Laure, Wang, Haiping, Ercolano, Giuseppe, Ahmed, Rita, Lozano, Leyder Elena, Ianaro, Angela, Derré, Laurent, Valerio, Massimo, Tawadros, Thomas, Jichlinski, Patrice, Nguyen-Ngoc, Tu, Speiser, Daniel E., Verdeil, Grégory, Gestermann, Nicolas, Dormond, Olivier, Kandalaft, Lana, Coukos, George, Jandus, Camilla, Ménétrier-Caux, Christine, Caux, Christophe, Ho, Ping-Chih, Romero, Pedro, Harari, Alexandre, Vigano, Selena
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2019
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6788118/
https://ncbi.nlm.nih.gov/pubmed/31601268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40425-019-0719-5
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