Inherited genetic susceptibility to acute lymphoblastic leukemia in Down syndrome

Children with Down syndrome (DS) have a 20-fold increased risk of acute lymphoblastic leukemia (ALL) and distinct somatic features, including CRLF2 rearrangement in ∼50% of cases; however, the role of inherited genetic variation in DS-ALL susceptibility is unknown. We report the first genome-wide as...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Brown, Austin L., de Smith, Adam J., Gant, Vincent U., Yang, Wenjian, Scheurer, Michael E., Walsh, Kyle M., Chernus, Jonathan M., Kallsen, Noah A., Peyton, Shanna A., Davies, Gareth E., Ehli, Erik A., Winick, Naomi, Heerema, Nyla A., Carroll, Andrew J., Borowitz, Michael J., Wood, Brent L., Carroll, William L., Raetz, Elizabeth A., Feingold, Eleanor, Devidas, Meenakshi, Barcellos, Lisa F., Hansen, Helen M., Morimoto, Libby, Kang, Alice Y., Smirnov, Ivan, Healy, Jasmine, Laverdière, Caroline, Sinnett, Daniel, Taub, Jeffrey W., Birch, Jillian M., Thompson, Pamela, Spector, Logan G., Pombo-de-Oliveira, Maria S., DeWan, Andrew T., Mullighan, Charles G., Hunger, Stephen P., Pui, Ching-Hon, Loh, Mignon L., Zwick, Michael E., Metayer, Catherine, Ma, Xiaomei, Mueller, Beth A., Sherman, Stephanie L., Wiemels, Joseph L., Relling, Mary V., Yang, Jun J., Lupo, Philip J., Rabin, Karen R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2019
Assuntos:
Lymphoid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6788009/
https://ncbi.nlm.nih.gov/pubmed/31350265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2018890764
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