Inherited genetic susceptibility to acute lymphoblastic leukemia in Down syndrome

Children with Down syndrome (DS) have a 20-fold increased risk of acute lymphoblastic leukemia (ALL) and distinct somatic features, including CRLF2 rearrangement in ∼50% of cases; however, the role of inherited genetic variation in DS-ALL susceptibility is unknown. We report the first genome-wide as...

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Pubblicato in:Blood
Autori principali: Brown, Austin L., de Smith, Adam J., Gant, Vincent U., Yang, Wenjian, Scheurer, Michael E., Walsh, Kyle M., Chernus, Jonathan M., Kallsen, Noah A., Peyton, Shanna A., Davies, Gareth E., Ehli, Erik A., Winick, Naomi, Heerema, Nyla A., Carroll, Andrew J., Borowitz, Michael J., Wood, Brent L., Carroll, William L., Raetz, Elizabeth A., Feingold, Eleanor, Devidas, Meenakshi, Barcellos, Lisa F., Hansen, Helen M., Morimoto, Libby, Kang, Alice Y., Smirnov, Ivan, Healy, Jasmine, Laverdière, Caroline, Sinnett, Daniel, Taub, Jeffrey W., Birch, Jillian M., Thompson, Pamela, Spector, Logan G., Pombo-de-Oliveira, Maria S., DeWan, Andrew T., Mullighan, Charles G., Hunger, Stephen P., Pui, Ching-Hon, Loh, Mignon L., Zwick, Michael E., Metayer, Catherine, Ma, Xiaomei, Mueller, Beth A., Sherman, Stephanie L., Wiemels, Joseph L., Relling, Mary V., Yang, Jun J., Lupo, Philip J., Rabin, Karen R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2019
Soggetti:
Lymphoid Neoplasia
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6788009/
https://ncbi.nlm.nih.gov/pubmed/31350265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2018890764
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