Cathepsin B increases ENaC activity leading to hypertension early in nephrotic syndrome

The NPHS2 gene, encoding the slit diaphragm protein podocin, accounts for genetic and sporadic forms of nephrotic syndrome (NS). Patients with NS often present symptoms of volume retention, such as oedema formation or hypertension. The primary dysregulation in sodium handling involves an inappropria...

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Detalhes bibliográficos
Publicado no:J Cell Mol Med
Main Authors: Larionov, Alexey, Dahlke, Eileen, Kunke, Madlen, Zanon Rodriguez, Luis, Schiessl, Ina M., Magnin, Jean‐Luc, Kern, Ursula, Alli, Abdel A., Mollet, Geraldine, Schilling, Oliver, Castrop, Hayo, Theilig, Franziska
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6787568/
https://ncbi.nlm.nih.gov/pubmed/31368174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.14387
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