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DNA sequence-dependent chromatin architecture and nuclear hubs formation

In this study, by exploring chromatin conformation capture data, we show that the nuclear segregation of Topologically Associated Domains (TADs) is contributed by DNA sequence composition. GC-peaks and valleys of TADs strongly influence interchromosomal interactions and chromatin 3D structure. To ga...

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書目詳細資料
發表在:Sci Rep
Main Authors: Jabbari, Kamel, Chakraborty, Maharshi, Wiehe, Thomas
格式: Artigo
語言:Inglês
出版: Nature Publishing Group UK 2019
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6787200/
https://ncbi.nlm.nih.gov/pubmed/31601866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-51036-9
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