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DNA sequence-dependent chromatin architecture and nuclear hubs formation
In this study, by exploring chromatin conformation capture data, we show that the nuclear segregation of Topologically Associated Domains (TADs) is contributed by DNA sequence composition. GC-peaks and valleys of TADs strongly influence interchromosomal interactions and chromatin 3D structure. To ga...
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| 發表在: | Sci Rep |
|---|---|
| Main Authors: | , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Nature Publishing Group UK
2019
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6787200/ https://ncbi.nlm.nih.gov/pubmed/31601866 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-51036-9 |
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