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SAHA modification of chromatin architecture affects DNA break formation and repair
PURPOSE: Chromatin modifying compounds that inhibit the activity of histone deacetylases have shown potency as radiosensitizers but the action of these drugs at a molecular level is not clear. Here we investigated the effect of SAHA on DNA breaks, their repair and induction of rearrangements. METHOD...
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| 主要な著者: | , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2010
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2818091/ https://ncbi.nlm.nih.gov/pubmed/20117292 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijrobp.2009.08.031 |
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