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Combining CDK4/6 inhibitors ribociclib and palbociclib with cytotoxic agents does not enhance cytotoxicity

Cyclin-dependent kinases 4 and 6 (CDK4/6) play critical roles in the G(1) to S checkpoint of the cell cycle and have been shown to be overactive in several human cancers. Small-molecule inhibitors of CDK4/6 have demonstrated significant efficacy against many solid tumors. Since CDK4/6 inhibition is...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Jin, Dan, Tran, Nguyen, Thomas, Nagheme, Tran, David D.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6786609/
https://ncbi.nlm.nih.gov/pubmed/31600301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0223555
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