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Combining CDK4/6 inhibitors ribociclib and palbociclib with cytotoxic agents does not enhance cytotoxicity
Cyclin-dependent kinases 4 and 6 (CDK4/6) play critical roles in the G(1) to S checkpoint of the cell cycle and have been shown to be overactive in several human cancers. Small-molecule inhibitors of CDK4/6 have demonstrated significant efficacy against many solid tumors. Since CDK4/6 inhibition is...
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| Publicado en: | PLoS One |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Public Library of Science
2019
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6786609/ https://ncbi.nlm.nih.gov/pubmed/31600301 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0223555 |
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