Simultaneous Combination of the CDK4/6 Inhibitor Palbociclib With Regorafenib Induces Enhanced Anti-tumor Effects in Hepatocarcinoma Cell Lines

Advanced hepatocarcinoma (HCC) is an aggressive malignancy with poor prognosis and limited treatment options. Alterations of the cyclin D-CDK4/6-Rb pathway occur frequently in HCC, providing the rationale for its targeting at least in a molecular subset of HCC. In a panel of HCC cell lines, we inves...

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Detalhes bibliográficos
Publicado no:Front Oncol
Main Authors: Digiacomo, Graziana, Fumarola, Claudia, La Monica, Silvia, Bonelli, Mara A., Cretella, Daniele, Alfieri, Roberta, Cavazzoni, Andrea, Galetti, Maricla, Bertolini, Patrizia, Missale, Gabriele, Petronini, Pier Giorgio
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Oncology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7539564/
https://ncbi.nlm.nih.gov/pubmed/33072590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2020.563249
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