Japanese nationwide survey of hypophosphatasia reveals prominent differences in genetic and dental findings between odonto and non-odonto types

Hypophosphatasia (HPP) is a rare and intractable metabolic bone disease caused by mutations in the ALPL gene. Here, we undertook a nationwide survey of HPP in Japan, specifically regarding the prominent genetic and dental manifestations of odonto (n = 16 cases) and other (termed “non-odonto”) (n = 3...

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Détails bibliographiques
Publié dans:PLoS One
Auteurs principaux: Okawa, Rena, Kokomoto, Kazuma, Kitaoka, Taichi, Kubota, Takuo, Watanabe, Atsushi, Taketani, Takeshi, Michigami, Toshimi, Ozono, Keiichi, Nakano, Kazuhiko
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2019
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6786601/
https://ncbi.nlm.nih.gov/pubmed/31600233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0222931
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