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Influences of an NR1I2 polymorphism on heterogeneous antiplatelet reactivity responses to clopidogrel and clinical outcomes in acute ischemic stroke patients

Pregnane X receptor (PXR) is a member of nuclear receptor subfamily 1 (NR1I2) that is a transcriptional regulator of several metabolic enzymes involved in clopidogrel metabolism. In this study we identified and evaluated the contributions of single nucleotide polymorphisms (SNPs) in NR1I2 and cytoch...

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Detalhes bibliográficos
Publicado no:Acta Pharmacol Sin
Main Authors: Chen, Yi-bei, Zhou, Zi-yi, Li, Guo-min, Xiao, Can-xing, Yu, Wei-bang, Zhong, Shi-long, Cai, Ye-feng, Jin, Jing, Huang, Min
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6786370/
https://ncbi.nlm.nih.gov/pubmed/30487649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41401-018-0178-4
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