Associations of CYP3A4, NR1I2, CYP2C19 and P2RY12 polymorphisms with clopidogrel resistance in Chinese patients with ischemic stroke

AIM: There is a high incidence of the antiplatelet drug clopidogrel resistance (CR) in Asian populations. Because clopidogrel is a prodrug, polymorphisms of genes encoding the enzymes involved in its biotransformation may be the primary influential factors. The goal of this study was to investigate...

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Detalhes bibliográficos
Publicado no:Acta Pharmacol Sin
Main Authors: Liu, Rui, Zhou, Zi-yi, Chen, Yi-bei, Li, Jia-li, Yu, Wei-bang, Chen, Xin-meng, Zhao, Min, Zhao, Yuan-qi, Cai, Ye-feng, Jin, Jing, Huang, Min
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4933760/
https://ncbi.nlm.nih.gov/pubmed/27133299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2016.41
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