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Formation, Reactivity, and Antiplatelet Activity of Mixed Disulfide Conjugates of Clopidogrel
In this work, we investigated the formation, reactivity, and antiplatelet activity of various mixed disulfide conjugates of clopidogrel. Our results showed that the production of the active metabolite (AM) from 2-oxoclopidogrel by human liver microsomes (HLMs) is greatly affected by the thiol reduct...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Pharmacology and Experimental Therapeutics
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3608439/ https://ncbi.nlm.nih.gov/pubmed/23348501 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.112.084392 |
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