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Propofol attenuates TNF-α-induced MMP-9 expression in human cerebral microvascular endothelial cells by inhibiting Ca(2+)/CAMK II/ERK/NF-κB signaling pathway

Metalloproteinase 9 (MMP-9) is able to degrade collagen IV, an important component of blood–brain barrier (BBB). Expression of MMPs, especially MMP-9, correlates with BBB disruption during central nervous system inflammation. Propofol has been reported to have anti-inflammation effects. In this stud...

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Bibliografiske detaljer
Udgivet i:Acta Pharmacol Sin
Main Authors: Ding, Xiao-wei, Sun, Xia, Shen, Xue-fang, Lu, Yan, Wang, Jia-qiang, Sun, Zhi-rong, Miao, Chang-hong, Chen, Jia-wei
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6786358/
https://ncbi.nlm.nih.gov/pubmed/31235816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41401-019-0258-0
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