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Propofol attenuates TNF-α-induced MMP-9 expression in human cerebral microvascular endothelial cells by inhibiting Ca(2+)/CAMK II/ERK/NF-κB signaling pathway
Metalloproteinase 9 (MMP-9) is able to degrade collagen IV, an important component of blood–brain barrier (BBB). Expression of MMPs, especially MMP-9, correlates with BBB disruption during central nervous system inflammation. Propofol has been reported to have anti-inflammation effects. In this stud...
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Udgivet i: | Acta Pharmacol Sin |
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Main Authors: | , , , , , , , |
Format: | Artigo |
Sprog: | Inglês |
Udgivet: |
Nature Publishing Group UK
2019
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Fag: | |
Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6786358/ https://ncbi.nlm.nih.gov/pubmed/31235816 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41401-019-0258-0 |
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