Construction of a novel MK-4 biosynthetic pathway in Pichia pastoris through heterologous expression of HsUBIAD1

BACKGROUND: With a variety of physiological and pharmacological functions, menaquinone is an essential prenylated product that can be endogenously converted from phylloquinone (VK(1)) or menadione (VK(3)) via the expression of Homo sapiens UBIAD1 (HsUBIAD1). The methylotrophic yeast, Pichia pastoris...

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Enregistré dans:
Détails bibliographiques
Publié dans:Microb Cell Fact
Auteurs principaux: Sun, Xiaowen, Liu, Hui, Wang, Peng, wang, Li, Ni, Wenfeng, Yang, Qiang, Wang, Han, Tang, Hengfang, Zhao, Genhai, Zheng, Zhiming
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2019
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6786277/
https://ncbi.nlm.nih.gov/pubmed/31601211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12934-019-1215-9
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