Construction of a novel MK-4 biosynthetic pathway in Pichia pastoris through heterologous expression of HsUBIAD1

BACKGROUND: With a variety of physiological and pharmacological functions, menaquinone is an essential prenylated product that can be endogenously converted from phylloquinone (VK(1)) or menadione (VK(3)) via the expression of Homo sapiens UBIAD1 (HsUBIAD1). The methylotrophic yeast, Pichia pastoris...

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Detalhes bibliográficos
Publicado no:Microb Cell Fact
Main Authors: Sun, Xiaowen, Liu, Hui, Wang, Peng, wang, Li, Ni, Wenfeng, Yang, Qiang, Wang, Han, Tang, Hengfang, Zhao, Genhai, Zheng, Zhiming
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6786277/
https://ncbi.nlm.nih.gov/pubmed/31601211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12934-019-1215-9
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