Tumor Imaging Using Radiolabeled Matrix Metalloproteinase–Activated Anthrax Proteins

Increased activity of matrix metalloproteinases (MMPs) is associated with worse prognosis in different cancer types. The wild-type protective antigen (PA-WT) of the binary anthrax lethal toxin was modified to form a pore in cell membranes only when cleaved by MMPs (to form PA-L1). Anthrax lethal fac...

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Dettagli Bibliografici
Pubblicato in:J Nucl Med
Autori principali: Elvina Xavier, Mary-Ann, Liu, Shihui, Bugge, Thomas H., Torres, Julia Baguña, Mosley, Michael, Hopkins, Samantha L., Allen, Phillip D., Berridge, Georgina, Vendrell, Iolanda, Fischer, Roman, Kersemans, Veerle, Smart, Sean, Leppla, Stephen H., Cornelissen, Bart
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society of Nuclear Medicine 2019
Soggetti:
Molecular Imaging
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6785798/
https://ncbi.nlm.nih.gov/pubmed/30954944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2967/jnumed.119.226423
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