Antiviral activity of a purine synthesis enzyme reveals a key role of deamidation in regulating protein nuclear import

Protein nuclear translocation is highly regulated and crucial for diverse biological processes. However, our understanding concerning protein nuclear import is incomplete. Here we report that a cellular purine synthesis enzyme inhibits protein nuclear import via deamidation. Employing human Kaposi’s...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Li, Junhua, Zhao, Jun, Xu, Simin, Zhang, Shu, Zhang, Junjie, Xiao, Jun, Gao, Ruoyun, Tian, Mao, Zeng, Yi, Lee, Katie, Tarakanova, Vera, Lan, Ke, Feng, Hao, Feng, Pinghui
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2019
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6785261/
https://ncbi.nlm.nih.gov/pubmed/31633017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aaw7373
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