Antiviral activity of a purine synthesis enzyme reveals a key role of deamidation in regulating protein nuclear import

Protein nuclear translocation is highly regulated and crucial for diverse biological processes. However, our understanding concerning protein nuclear import is incomplete. Here we report that a cellular purine synthesis enzyme inhibits protein nuclear import via deamidation. Employing human Kaposi’s...

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Publicat a:Sci Adv
Autors principals: Li, Junhua, Zhao, Jun, Xu, Simin, Zhang, Shu, Zhang, Junjie, Xiao, Jun, Gao, Ruoyun, Tian, Mao, Zeng, Yi, Lee, Katie, Tarakanova, Vera, Lan, Ke, Feng, Hao, Feng, Pinghui
Format: Artigo
Idioma:Inglês
Publicat: American Association for the Advancement of Science 2019
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6785261/
https://ncbi.nlm.nih.gov/pubmed/31633017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aaw7373
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