Viral Pseudo Enzymes Activate RIG-I via Deamidation to Evade Cytokine Production

RIG-I is a pattern recognition receptor that senses viral RNA and is crucial for host innate immune defense. Here we describe a mechanism of RIG-I activation through amidotransferase-mediated deamidation. We show that viral homologues of phosphoribosylformyglycinamide synthase (PFAS), although lacki...

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Detalhes bibliográficos
Publicado no:Mol Cell
Main Authors: He, Shanping, Zhao, Jun, Song, Shanshan, He, Xiaojing, Minassian, Arlet, Zhou, Yu, Zhang, Junjie, Brulois, Kevin, Wang, Yuqi, Cabo, Jackson, Zandi, Ebrahim, Liang, Chengyu, Jung, Jae U, Zhang, Xuewu, Feng, Pinghui
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4385502/
https://ncbi.nlm.nih.gov/pubmed/25752576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2015.01.036
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