Impaired anandamide/palmitoylethanolamide signaling in hippocampal glutamatergic neurons alters synaptic plasticity, learning, and emotional responses

Endocannabinoid signaling via anandamide (AEA) is implicated in a variety of neuronal functions and considered a promising therapeutic target for numerous emotion-related disorders. The major AEA degrading enzyme is fatty acid amide hydrolase (FAAH). Genetic deletion and pharmacological inhibition o...

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Detalhes bibliográficos
Publicado no:Neuropsychopharmacology
Main Authors: Zimmermann, Tina, Bartsch, Julia C., Beer, Annika, Lomazzo, Ermelinda, Guggenhuber, Stephan, Lange, Maren D., Bindila, Laura, Pape, Hans-Christian, Lutz, Beat
Formato: Artigo
Idioma:Inglês
Publicado em: Springer International Publishing 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6784910/
https://ncbi.nlm.nih.gov/pubmed/30532004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41386-018-0274-7
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