Impaired 2-AG Signaling in Hippocampal Glutamatergic Neurons: Aggravation of Anxiety-Like Behavior and Unaltered Seizure Susceptibility

BACKGROUND: Postsynaptically generated 2-arachidonoylglycerol activates the presynaptic cannabinoid type-1 receptor, which is involved in synaptic plasticity at both glutamatergic and GABAergic synapses. However, the differential function of 2-arachidonoylglycerol signaling at glutamatergic vs GABAe...

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Detalhes bibliográficos
Publicado no:Int J Neuropsychopharmacol
Main Authors: Guggenhuber, Stephan, Romo-Parra, Hector, Bindila, Laura, Leschik, Julia, Lomazzo, Ermelinda, Remmers, Floortje, Zimmermann, Tina, Lerner, Raissa, Klugmann, Matthias, Pape, Hans-Christian, Lutz, Beat
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4772822/
https://ncbi.nlm.nih.gov/pubmed/26232789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ijnp/pyv091
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