A frizzled-like cysteine rich domain in glypican-3 mediates Wnt binding and regulates hepatocellular carcinoma tumor growth in mice

Wnt signaling is one of the key regulators of hepatocellular carcinoma (HCC) tumor progression. In addition to the classical receptor frizzled (FZD), various co-receptors including heparan sulfate proteoglycans (HSPGs) are involved in Wnt activation. Glypican-3 (GPC3) is a HSPG that is overexpressed...

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Publicado no:Hepatology
Main Authors: Li, Na, Wei, Liwen, Liu, Xiaoyu, Bai, Hongjun, Ye, Yvonne, Li, Dan, Li, Nan, Baxa, Ulrich, Wang, Qun, Lv, Ling, Chen, Yun, Feng, Mingqian, Lee, Byungkook, Gao, Wei, Ho, Mitchell
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6783318/
https://ncbi.nlm.nih.gov/pubmed/30963603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.30646
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