Evolution of (p)ppGpp-HPRT regulation through diversification of an allosteric oligomeric interaction

The alarmone (p)ppGpp regulates diverse targets, yet its target specificity and evolution remain poorly understood. Here, we elucidate the mechanism by which basal (p)ppGpp inhibits the purine salvage enzyme HPRT by sharing a conserved motif with its substrate PRPP. Intriguingly, HPRT regulation by...

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Publicat a:eLife
Autors principals: Anderson, Brent W, Liu, Kuanqing, Wolak, Christine, Dubiel, Katarzyna, She, Fukang, Satyshur, Kenneth A, Keck, James L, Wang, Jue D
Format: Artigo
Idioma:Inglês
Publicat: eLife Sciences Publications, Ltd 2019
Matèries:
Biochemistry and Chemical Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6783271/
https://ncbi.nlm.nih.gov/pubmed/31552824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.47534
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