Truncated Apolipoprotein E (ApoE) Causes Increased Intracellular Calcium and May Mediate ApoE Neurotoxicity

Apolipoprotein E (apoE)-related synthetic peptides, the 22 kDa N-terminal thrombin-cleavage fragment of apoE (truncated apoE), and full-length apoE have all been shown to exhibit neurotoxic activity under certain culture conditions. In the present study, protease inhibitors reduced the neurotoxicity...

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Pubblicato in:J Neurosci
Autori principali: Tolar, Martin, Keller, Jeffrey N., Chan, Stephen, Mattson, Mark P., Marques, Marcos A., Crutcher, Keith A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 1999
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6782866/
https://ncbi.nlm.nih.gov/pubmed/10436064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.19-16-07100.1999
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