Protofibrillar Intermediates of Amyloid β-Protein Induce Acute Electrophysiological Changes and Progressive Neurotoxicity in Cortical Neurons

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that is thought to be caused in part by the age-related accumulation of amyloid β-protein (Aβ). The presence of neuritic plaques containing abundant Aβ-derived amyloid fibrils in AD brain tissue supports the concept that fibril acc...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Hartley, Dean M., Walsh, Dominic M., Ye, Chianping P., Diehl, Thekla, Vasquez, Sara, Vassilev, Peter M., Teplow, David B., Selkoe, Dennis. J.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 1999
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6782787/
https://ncbi.nlm.nih.gov/pubmed/10516307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.19-20-08876.1999
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