RNA Oxidation Is a Prominent Feature of Vulnerable Neurons in Alzheimer’s Disease

In this study we used an in situ approach to identify the oxidized nucleosides 8-hydroxydeoxyguanosine (8OHdG) and 8-hydroxyguanosine (8OHG), markers of oxidative damage to DNA and RNA, respectively, in cases of Alzheimer’s disease (AD). The goal was to determine whether nuclear and mitochondrial DN...

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Détails bibliographiques
Publié dans:J Neurosci
Auteurs principaux: Nunomura, Akihiko, Perry, George, Pappolla, Miguel A., Wade, Ramon, Hirai, Keisuke, Chiba, Shigeru, Smith, Mark A.
Format: Artigo
Langue:Inglês
Publié: Society for Neuroscience 1999
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6782583/
https://ncbi.nlm.nih.gov/pubmed/10066249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.19-06-01959.1999
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