The Earliest Stage of Cognitive Impairment in Transition From Normal Aging to Alzheimer Disease Is Marked By Prominent RNA Oxidation in Vulnerable Neurons

Although neuronal RNA oxidation is a prominent and established feature in age-associated neurodegenerative disorders such as Alzheimer disease (AD), oxidative damage to neuronal RNA in aging and in the transitional stages from normal elderly to the onset of AD has not been fully examined. In this st...

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Main Authors: Nunomura, Akihiko, Tamaoki, Toshio, Motohashi, Nobutaka, Nakamura, Masao, McKeel, Daniel W., Tabaton, Massimo, Lee, Hyoung-gon, Smith, Mark A., Perry, George, Zhu, Xiongwei
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3288284/
https://ncbi.nlm.nih.gov/pubmed/22318126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/NEN.0b013e318248e614
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