Akt-Dependent Potentiation of L Channels by Insulin-Like Growth Factor-1 Is Required for Neuronal Survival

The insulin-like growth factor-1 (IGF-1)/receptor tyrosine kinase recently has been shown to mediate neuronal survival and potentiate the activity of specific calcium channel subtypes; survival requires Akt, a serine/threonine kinase. We demonstrate here that Akt mediates the IGF-1-induced potentiat...

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Bibliographic Details
Published in:J Neurosci
Main Authors: Blair, Leslie A. C., Bence-Hanulec, Kendra K., Mehta, Sunil, Franke, Thomas, Kaplan, David, Marshall, John
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 1999
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6782565/
https://ncbi.nlm.nih.gov/pubmed/10066247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.19-06-01940.1999
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