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Akt1 and Akt2 are required for αβ thymocyte survival and differentiation
The β-selection checkpoint in αβT lymphocyte development occurs at the double negative (DN) 3 (CD4(−)CD8(−)CD25(+)c-kit(−)) stage, when further differentiation requires a signal from the newly rearranged TCR β chain. Thymocytes with mutations in key signaling molecules in the phosphatidylinositol 3-...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1924580/ https://ncbi.nlm.nih.gov/pubmed/17609365 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0705285104 |
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